讓你上癮的咖啡因，就是這樣殺死你的健康的。

最近微信改版，容易找不到尹哥的文章，大家記得把尹哥設(shè)為星標(biāo)?? 哦~

· 俗話說(shuō)，不談劑量只談危害，本就缺乏科學(xué)依據(jù)。網(wǎng)絡(luò)上不少為咖啡辟謠的內(nèi)容，往往刻意忽略咖啡因攝入總量，一味片面宣揚(yáng)咖啡完全無(wú)害。

· 如今咖啡早已融入大眾日常生活，很多人習(xí)慣飲用高濃度咖啡。再加上日常茶飲、碳酸飲料中也含有咖啡因，越來(lái)越多人長(zhǎng)期存在咖啡因過(guò)量攝入的問(wèn)題，在不知不覺(jué)間損害身體健康。本身患有胃病、肝臟代謝疾病，或是免疫力低下的人群，受到的負(fù)面影響會(huì)更加嚴(yán)重。

· 若是一味將咖啡塑造成絕對(duì)無(wú)害的飲品，這類(lèi)特殊人群便會(huì)放松戒備，忽視咖啡因帶來(lái)的潛在傷害。進(jìn)而毫無(wú)節(jié)制地隨意飲用，讓自身健康持續(xù)暴露在風(fēng)險(xiǎn)之中。

· 咖啡本身是一把雙刃劍，利弊并存。把控好飲用的尺度與頻率，適度攝入能夠?qū)ι眢w產(chǎn)生益處，可一旦長(zhǎng)期過(guò)量飲用，便會(huì)反噬身體，引發(fā)多種健康問(wèn)題。

參考資料：

[1] Zivkovi? R. Coffee and health in the elderly. Acta Med Croatica. 2000;54(1):33-6. PMID: 10914439.

[2] Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol. 2004 Jan;94(1):13-8. PMID: 14725610.

[3] Crozier TW, Stalmach A, Lean ME, Crozier A. Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food Funct. 2012 Jan;3(1):30-3. doi: 10.1039/c1fo10240k. Epub 2011 Nov 30. PMID: 22130653.

[4] Ludwig IA, Mena P, Calani L, Cid C, Del Rio D, Lean ME, Crozier A. Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? Food Funct. 2014 Aug;5(8):1718-26. doi: 10.1039/c4fo00290c. PMID: 25014672.

[5] Silletta MG, Marchioli R. Caffè rischio di malattie cardiovascolari: yin e yang [Coffee and cardiovascular disease risk: yin and yang]. Recenti Prog Med. 2008 Nov;99(11):533-7. Italian. PMID: 19209536.

[6] Glover FE, Caudle WM, Del Giudice F, Belladelli F, Mulloy E, Lawal E, Eisenberg ML. The association between caffeine intake and testosterone: NHANES 2013-2014. Nutr J. 2022 May 17;21(1):33. doi: 10.1186/s12937-022-00783-z. PMID: 35578259; PMCID: PMC9112543.

[7] Paz-Graniel I, Kose J, Babio N, Hercberg S, Galan P, Touvier M, Salas-Salvadó J, Andreeva VA. Caffeine Intake and Its Sex-Specific Association with General [8] Anxiety: A Cross-Sectional Analysis among General Population Adults. Nutrients. 2022 Mar 15;14(6):1242. doi: 10.3390/nu14061242. PMID: 35334898; PMCID: PMC8951500.

[9] Zhang WZ, Sun NN, Hu Y, Cao Y, Amber S. Caffeine Exposure Causes Immune Dysfunction and Intrauterine Growth Restriction Retardation in Rats. Biomed Environ Sci. 2022 Feb 20;35(2):170-173. doi: 10.3967/bes2022.025. PMID: 35197185.

[10] Fortier I, Marcoux S, Beaulac-Baillargeon L. Relation of caffeine intake during pregnancy to intrauterine growth retardation and preterm birth. Am J Epidemiol. 1993 May 1;137(9):931-40. doi: 10.1093/oxfordjournals.aje.a116763. PMID: 8317450.

[11] Purdue-Smithe AC, Kim K, Schliep KC, DeVilbiss EA, Hinkle SN, Ye A, Perkins NJ, Sjaarda LA, Silver RM, Schisterman EF, Mumford SL. Preconception caffeine metabolites, caffeinated beverage intake, and fecundability. Am J Clin Nutr. 2022 Apr 1;115(4):1227-1236. doi: 10.1093/ajcn/nqab435. PMID: 35030239; PMCID: PMC8970989.

[12] Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017 Nov 22;359:j5024. doi: 10.1136/bmj.j5024. Erratum in: BMJ. 2018 Jan 12;360:k194. PMID: 29167102; PMCID: PMC5696634.

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